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1.1.14 Maternal toxicity. Miconazole is an equine antimicrobial agents, and may induce hyperbilirubinemia in pregnant women. Signs of a hyperbilirubinemia can include dilated pupils, respiratory distress with wheezing, and a low grade fever. Miconazole is also toxic in a variety of other systems, including cardiovascular and renal. Miconazole has demonstrated anti-proliferative actions in human carcinoma and leukemia xenograft models (i.e. T22A cells) with a single dose of 200 mg/kg and mg/kg, respectively. In these studies no increase to the risk for teratogenicity was identified. Further research is required to fully clarify the risk profile of miconazole in pregnancy. is not known to cause any drug-induced congenital abnormalities in humans.
1.2 Antifungal effects. Miconazole inhibits fungal growths including A. fumigatus and niger. Miconazole was not toxic in vitro to all the A. fumigatus growth, and potency of miconazole was not dependent on pH. However, due to the pH range in humans, it has not been possible to assess the in vitro cytotoxic effect of concentrations within the range considered safe when used as standard therapeutics. It would be reasonable, therefore, to consider miconazole in combination with other drugs against A. fumigatus.
1.3 Effects on reproductive capacity. Miconazole may inhibit fertilisation in rats (Drs. Smedley and Hargraves, 1994). Miconazole was inactive in the male reproductive system at 25mg/kg and 100mg/kg when administered for 5 consecutive days (Drs. M. Smedley and G. D. Hargraves, Personal communication, 1997). Miconazole can be administered in amounts as high 100mg/kg orally (T. R. L. Jones, personal communication, 1996; A. S. Fossey et al., 1992). These studies indicate that miconazole may be toxic to male reproductive organs.
1.4 Interactions with other drugs. Miconazole is an orally active drug, which may Cardura 2mg $303.26 - $0.84 Per pill result in serious interactions with prescribed pharmaceutical products. It is generally accepted that miconazole can reduce the bioavailability of antifungal drugs in rats and rabbits, may have clinically significant effects upon human health during treatment with trifosfomycin. This is cardura 2 mg generico due mainly to its inhibition of cytochrome P450 enzymes. It may also reduce the activity of cytochrome P450 enzymes and increase the metabolic rate of organism. As a result it was suggested that may be more effective as an antitumour agent than trifosfomycin (Bohor and Bekes, 1984). The activity of miconazole on cytochrome P450 enzymes has an impact on the therapeutic drug concentration in a number of different metabolic pathways (Bohor and Vaziriou, 1998). This may result in a dose-response profile that may be unpredictable (Bohor and Vaziriou, 1998). It may have a clinical impact upon therapeutic pharmacokinetics due to the inhibition of CYP3A and/or CYP2E1 enzymes.
For this reason some clinical data has been published about the relationship between use of drugs (including trifosfomycin) used in the treatment of fungal infections (i.e. A.f. infections) and the use of miconazole (A.f. neofungales). has not been shown to have any direct toxic
Bimatoprost colirio precio effect on patients using trifosfomycin alone. cardura 2 mg cena Although the trifosfomycin-only group had higher cumulative doses (AUC 0 –∞ ) the mean trough concentrations of miconazole (AUC 0 –∞ ) were similar between groups. This is consistent with other data that shows trifosfomycin, in particular, is not a problem with miconazole. The most relevant clinical data in this context are the authors' experience of using a miconazole dosage 200mg, given by mouth with trifosfomycin 1g on the same day (S. S. Johnson and D. G. Bekes, personal communication, 1997). When used with trifosfomycin 1g, the
cardura xl 8 mg cena effect on serum concentrations is more marked as it can reduce total trifosfomycin concentrations in the body up to.
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