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Bactrim - a combined drug, containing two active ingredients: sulfanamide drug sulfamethoxazole and derivative of diaminopyrimidine - trimethoprimum. Colibacillus life activity oppresses that leads to reduction of synthesis of thymine, riboflavinum, niacin, etc. group B vitamins in intestines. Duration of therapeutic effect makes 7 years.
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An antifungal agent from the group of imidazole derivatives for external and local applications reduces the synthesis of ergosterol, which is a part of the cell membrane of the microbial wall and leads to a change in its structure and properties. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, leading to an increase in the concentration of hydrogen peroxide to toxic levels, which also contributes to the destruction of fungal cells. The pills are active against pathogenic dermatophytes, pathogens of multi-colored lichen, erythrasma, gram-positive and gram-negative bacteria.
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Clotrimazole miconazole
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TABLE 8—Doxycycline- and macrolide-containing ointments for the treatment of rosacea: Active drug
Formulation Ingredient Other ingredients 1.5/0.15 1.5/0.30 0/0 1.5/0.10 0/1 1.5/0.35 1.0 1.2 1.6 2.2 0.4 2.1 0.2 Doxycycline 1,200 mg 4.0 1.8 3.5 0.8/0.5 5/2 100/1 0.1/2 0.2 Doxycyline 300 mg 4.0 1.8 0.8/0.5 5/2 100/1 0.1/2 0.2 Doxycycline-miconazole 30 mg 1.0 1.2 2.10 2.10/0.1 6/1.0 100/1 1.0 1.8 3.9 0.6 3.0 0.3 Doxycyline-miconazole 1.00 mg 2.0 An antifungal agent from the group of imidazole derivatives for external and local applications reduces the synthesis of ergosterol, which is a part of the cell membrane of the microbial wall and leads to a change in its structure and properties. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, leading to an increase in the concentration of hydrogen peroxide to toxic levels, which also contributes to the destruction of fungal cells. The pills are active against pathogenic dermatophytes, pathogens of multi-colored lichen, erythrasma, gram-positive and gram-negative bacteria. 0.9 2.1 0.5/0.8 6/2 100/1 0.1/2 0.2 Doxycyline 400 mg 2.0 2.2 2.4 0.7/0.8 5/2 100/1 0.1/2 0.2 Macrolide 400 mg 10.0 1.0 7.0 1.0/1.2 22/3 100/3 1.2/6 2.2/10 0.3 1.8/3 Doxycycline 300 mg 4.0 2.2 3.0 1.0/0.8 5/2 100/1 how much is clotrimazole pessary 0.0/1 1.5/1.0 0.2 Doxycyline 500 mg 1.5 1.2 2.70 2.40/0.8 6/0.5 100/1 0.0/1 1.5/1.0 0.2 Doxycycline-miconazole 35 mg 1.0 1.2 2.50 4.00/1.0 6/1.0 100/2 0.1/2 8.0/5 0.5 Doxycyline-miconazole 1.00 mg 1.5 1.0 3.20 3.20/0.2 4/1.0 100/1 0.1/1 1.0 7.2 14.0 0.4
Other oral medicines to increase how much clotrimazole is in lotrimin efficacy (i.e. corticosteroids, methotrexate, fluconazole) were examined as potential treatment modalities (p ≤ 0.05 compared with placebo group, Table 9).
In the rosacea group compared with placebo, the use of fluconazole resulted in significantly higher remission (p = 0.004 compared with p ≤ 0.05) as well overall improvement at week 7 (p = 0.02). However, the overall improvement observed during study period was small compared with the decrease seen fluconazole (p ≤ 0.05). The use of fluconazole significantly improved acne severity as measured by the ADAS-CESS scores and PASI score, whereas no significant difference was observed in these parameters between the groups. use of other oral antibiotics significantly increased remission and overall improvement in both groups. Fluconazole and roxithromycin, two clotrimazole how much does it cost other antibiotics, resulted in a similar remission, overall improvement, and reduction of inflammation, as observed in the rosacea group without significant changes in other clinical endpoints. the rosacea group compared with placebo, all these endpoints increased slightly (p ≤ 0.02).
Oral medication, including a number of oral antibiotics, was associated with statistically significant improvement of total lesions and pustules in at least one side of the face when compared with placebo (Table 9). However, the treatment benefits observed were limited, possibly because the effect on skin was so small (<1%) relative to the improvement observed in other parameters.
Discussion
To our knowledge, this is the largest placebo-controlled clinical trial in which the use of antibiotics for treatment rosacea has been evaluated in a large sample of patients from two continents. However, our results indicate that the effect size of treatment was small. In terms of total lesions and acne.
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