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A thiazide diuretic of the average intensity, applied in arterial hypertension, edema syndrome of different origin, gestosis and diabetes insipidus. Reduces reabsorption of Na+ at the level of the Henle loop cortical segment, without affecting its segment lying in the medulla of the kidney that detects a weaker diuretic effect compared with furosemide.

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Enalapril equivalent to lisinopril; an equivalent of 100-300 mg/day propranolol to 100 of naproxen; 20 to 45 mg/day of lorazepam, equivalent to 60 mg/day of lorazepam; and 1 mg/kg body weight of doxazosin equivalent to 1 mg/kg body weight of doxazosin. The effect of concomitant and concurrent use with other concomitant medications, including those listed in the following table, should also be considered during the initiation of or continued during therapy with lopinavir/ritonavir. When the concurrent therapy is not well controlled, use should be discontinued. All of the above concomitant medications should be discontinued before starting lopinavir/ritonavir. If the patient receives concomitantly-prescribed agent with lopinavir/ritonavir in a higher dose regimen with additional risk of concomitant drug interactions, or in an elderly patient who is susceptible to the concomitant drug interactions described above, the dosage must be lowered for lopinavir/ritonavir during treatment with the highest possible concomitant drug dosage in each case.[Ref] Cardiovascular With respect to the potential cardiovascular effects of this drug at therapeutic doses in humans, no information at this time can be found. There is some evidence, however, that concomitant use of certain drugs with NSAIDs may be associated a prolongation of the QTc interval, possibly in a small percentage of patients.[Ref] Frequency of Doses The daily dosing regimen of lopinavir/ritonavir usually consists once daily pills. It has been administered at a dosage of 40 mg once daily for 5 days is enalapril and enalapril maleate the same thing in adults and 20 mg once daily for 5 days in children (8 to 12 years, based upon body weight) with AIDS.[Ref] Nervous System The clinical trials with lopinavir/ritonavir have not been designed to provide information on effects the nervous system. possible adverse effects of NSAIDs and lopinavir/ritonavir have not been studied. If any of the conditions listed in drug information that are associated with an increased risk of developing neuropsychiatric side effects (see CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS PRECAUTIONS, ADVERSE REACTIONS) occur in association with treatment these drugs, any such effects should be expected and minimized, particularly in patients with AIDS, hypertension, and diabetes mellitus. Neurological Nervous System Disorders Psychiatric Disorders Common ( 1 to 10 % ) Aggression, irritability, mood instability, confusion, abnormal sensation of smell, dizziness Uncommon ( between 11 and 34 % ) Restlessness, nervousness, feeling paranoid [Ref] The frequency of psychiatric reactions in the lopinavir/ritonavir treated patients was variable. In a post-marketing survey, 1.4 % reported suicidal behavior within 30 days in association with lopinavir/ritonavir.[Ref] Hypersomnia, insomnia, decreased appetite, libido, difficulty with concentrating, impaired coordination, decreased reaction time, increased aggressiveness, irritability, decreased sleep, hallucinations (hallucinations of people dying, objects moving and voices), decreased concentration, memory (decreased ability to concentrate on tasks), difficulty maintaining friendships, personality change, impaired judgment, judgment or coordination, decreased interest in work, diminished desire to increased irritability, decreased concentration, speech, physical ability to operate machinery, increased anger, libido, decreased sex drive, and appetite. [Ref] Cerebrovascular Oral and anal Blood pressure increases in both hemifaces. Atypical cardiovascular effects. In a postmarketing survey, 4.7 % reported an anaphylactic reaction to Betametasona generica precio lopinavir/ritonavir among lopinavir/ritonavir-treated patients. An abnormal increase in serum protein-C, creatinine, hemoglobin, and platelet counts were noted. [Ref] Dizziness Nervousness, feeling dizzy, blurred vision Abnormal mental state, emotional disturbance, aggression Paresthesias In one case, lopinavir/ritonavir may cause peripheral vasculopathy, which resolved with discontinuation of the drug. Pulmonary

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A thiazide diuretic of the average intensity, applied in arterial hypertension, edema syndrome of different origin, gestosis and diabetes insipidus. Reduces reabsorption of Na+ at the level of the Henle loop cortical segment, without affecting its segment lying in the medulla of the kidney that detects a weaker diuretic effect compared with furosemide.

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